1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

Base Information

Chemical Name:1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate
CAS No.:1258855-60-5
Molecular Formula:C₂₇H₂₈F₂N₄O₄
Molecular Weight:510.541
Hs Code.:

1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

Synonyms:1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

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Chemical Property of 1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

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Technology Process of 1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

There total 6 articles about 1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 453-13-4
1,3-difluoro-2-propanol

: 1258855-51-4
1,1-dimethylethyl 7-[5-(3-cyano-4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-60-5
1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

Guidance literature:: 1,3-difluoro-2-propanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

1,1-dimethylethyl 7-[5-(3-cyano-4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 264264-28-0
1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1258855-60-5
1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.25 h / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 60 °C / Reflux

3: pyridine / toluene / 2 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 171050-06-9
3-cyano-4-fluorobenzoic acid

: 1258855-60-5
1,1-dimethylethyl 7-[5-(3-cyano-4-{[2-fluoro-l-(fluoromethyl)ethyl]oxy}phenyl)-1,2,4-oxadiazol-3-yl]-1,2,4,5-tetrahyd ro-3H-3-benzazepi ne-3-carboxyl ate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 0.25 h

2: pyridine / toluene / 2 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

With pyridine; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; toluene; mineral oil;