2-benzothiazolylmethylenetriphenylphosphorane

Base Information

• Chemical Name: 2-benzothiazolylmethylenetriphenylphosphorane
• CAS No.: 1628-68-8
• Molecular Formula: C₂₆H₂₀NPS
• Molecular Weight: 409.491
• Mol file: 1628-68-8.mol

Synonyms:2-benzothiazolylmethylenetriphenylphosphorane

Chemical Property of 2-benzothiazolylmethylenetriphenylphosphorane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzothiazolylmethylenetriphenylphosphorane

There total 9 articles about 2-benzothiazolylmethylenetriphenylphosphorane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-benzothiazolylmethyltriphenylphosphonium chloride (115792-17-1) → 2-benzothiazolylmethylenetriphenylphosphorane (1628-68-8)

Guidance literature:

With potassium tert-butylate; for 3h;

DOI:10.1016/S0040-4020(01)90345-X

Reference yield:

2-chloromethylbenzothiazole (37859-43-1) → 2-benzothiazolylmethylenetriphenylphosphorane (1628-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / toluene / 20 h / Heating

2: 85 percent / potassium tert-butoxide / 3 h

With potassium tert-butylate; In toluene;

DOI:10.1016/S0040-4020(01)90345-X

Reference yield:

1,3-benzothiazol-2-ylmethanol (37859-42-0) → 2-benzothiazolylmethylenetriphenylphosphorane (1628-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / triphenylphosphine / CCl₄; benzene / 2 h / Heating

2: 86 percent / toluene / 20 h / Heating

3: 85 percent / potassium tert-butoxide / 3 h

With potassium tert-butylate; triphenylphosphine; In tetrachloromethane; toluene; benzene;

DOI:10.1016/S0040-4020(01)90345-X

upstream raw materials:

(benzothiazole-2-ylmethyl)triphenylphosphonium bromide

2-benzothiazolylmethyltriphenylphosphonium chloride

2-chloromethylbenzothiazole

1,3-benzothiazol-2-ylmethanol

Downstream raw materials:

3-methyl-1-(2-benzothiazolyl)-(1E)-butene

(Z)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole

(E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole

(E)-2-[N-methyl-N-(2'-tosyloxyethyl)-4'-aminostyryl]benzothiazole

Refernces

• 1、 Dondoni, Alessandro,Fantin, Giancarlo,Fogagnolo, Marco,Medici, Alessandro,Pedrini, Paola. "THIAZOLYLMETHYLENETRIPHENYLPHOSPHORANE AND ITS BENZO DERIVATIVE: STABLE AND PRACTICAL WITTIG REAGENTS FOR THE SYNTHESIS OF VINYLTHIAZOLES AND VINYLBENZOTHIAZOLES. TWO-CARBON HOMOLOGATION OF ALDEHYDES.". . p. 2021 - 2032. Retrieved 2007/10/02.