(E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole

Base Information

• Chemical Name: (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole
• CAS No.: 1352300-05-0
• Molecular Formula: C₁₈H₁₇FN₂S
• Molecular Weight: 312.411
• Mol file: 1352300-05-0.mol

Synonyms:(E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole

Chemical Property of (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole

There total 6 articles about (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-[N-methyl-N-(2'-tosyloxyethyl)-4'-aminostyryl]benzothiazole (1352299-97-8) → (Z)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole (1352300-04-9) + (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole (1352300-05-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Reflux;

DOI:10.1016/j.bmc.2011.09.065

Reference yield:

2-chloromethylbenzothiazole (37859-43-1) → (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole (1352300-05-0)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene

2: potassium tert-butylate / benzene / 20 °C

3: tetrahydrofuran / Reflux

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Reflux

With potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene; benzene; 3: Wittig reaction;

DOI:10.1016/j.bmc.2011.09.065

Reference yield:

4-[N-methyl-N-(2-{[(4-methylphenyl)sulfonyloxy]ethyl}amino)]benzaldehyde (149265-10-1) → (E)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole (1352300-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / Reflux

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1: Wittig reaction;

DOI:10.1016/j.bmc.2011.09.065

upstream raw materials:

2-benzothiazolylmethylenetriphenylphosphorane

4-[N-methyl-N-(2-{[(4-methylphenyl)sulfonyloxy]ethyl}amino)]benzaldehyde

2-chloromethylbenzothiazole

(E)-2-[N-methyl-N-(2'-tosyloxyethyl)-4'-aminostyryl]benzothiazole

Downstream raw materials:

(Z)-2-[N-methyl-N-(2'-fluoroethyl)-4'-aminostyryl]benzothiazole