(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

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Chemical Name:(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid
CAS No.:1401728-67-3
Molecular Formula:C₂₀H₂₁N₃O₂
Molecular Weight:335.406
Hs Code.:

Synonyms:(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

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Chemical Property of (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

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Technology Process of (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

There total 5 articles about (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1401728-64-0
(E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester

: 1401728-67-3
(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

Guidance literature:: (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 60h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; pH=Ca. 3.5; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01703

Reference yield:

: 57775-08-3
3-(4-Bromo-phenyl)-propionitrile

: 1401728-67-3
(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 20 °C

1.2: 0.33 h / 20 °C

2.1: acetic acid; hydrazine hydrate / ethanol / 0.25 h / 140 °C / Microwave irradiation

2.2: 160 °C

3.1: trifluoroacetic acid / 1,4-dioxane / 20 °C

4.1: bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine / 1,4-dioxane / 0.08 h / 130 °C / Microwave irradiation

5.1: lithium hydroxide / tetrahydrofuran / 20 °C

With bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine; potassium 2-methylbutan-2-olate; hydrazine hydrate; acetic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;

Reference yield:

: 1401728-61-7
2-(4-bromobenzyl)-3-oxopentanenitrile

: 1401728-67-3
(E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; hydrazine hydrate / ethanol / 0.25 h / 140 °C / Microwave irradiation

1.2: 160 °C

2.1: trifluoroacetic acid / 1,4-dioxane / 20 °C

3.1: bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine / 1,4-dioxane / 0.08 h / 130 °C / Microwave irradiation

4.1: lithium hydroxide / tetrahydrofuran / 20 °C

With bis(tri-t-butylphosphine)palladium ⁽⁰⁾; N-Methyldicyclohexylamine; hydrazine hydrate; acetic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol;