1401728-64-0

Basic information

• Product Name: (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester
• Synonyms: (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester
• CAS NO: 1401728-64-0
• Molecular Weight: 349.433
• Mol File: 1401728-64-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester(1401728-64-0)
• EPA Substance Registry System: (E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]acrylic acid methyl ester(1401728-64-0)

Safety Data

• Hazardous Substances Data: 1401728-64-0(Hazardous Substances Data)

Upstream product

• 1401728-63-9 3-(4-bromobenzyl)-2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine 
• 292638-85-8 acrylic acid methyl ester 
• 57775-08-3 3-(4-Bromo-phenyl)-propionitrile 
• 1401728-62-8 4-(4-bromobenzyl)-5-ethyl-2H-pyrazol-3-ylamine 
• 1401728-61-7 2-(4-bromobenzyl)-3-oxopentanenitrile 

Downstream Products

• 1401728-67-3 (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylic acid 
• 1401729-01-8 (E)-tert-butyl 4-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acryloyl)piperazine-1-carboxylate 
• 1401729-02-9 tert-butyl 4-(3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)propanoyl)piperazine-1-carboxylate 
• 1401729-14-3 C₃₀H₄₁N₅O₃ 
• 1401728-66-2 (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)acrylaldehyde 
• 1401728-65-1 (E)-3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)prop-2-en-1-ol 
• 1401728-29-7 C₂₅H₃₃N₅ 
• 1401728-40-2 3-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride 
• 1401729-19-8 (R)-3-(4-{(E)-3-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenyl]allyl}piperazin-1-yl)propane-1,2-diol 
• 1401728-34-4 (E)-2-ethyl-5,7-dimethyl-3-(4-(3-(piperazin-1-yl)prop-1-enyl)benzyl)pyrazolo[1,5-a]pyrimidine 

Relevant articles and documents

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis

A novel, selective, and efficacious GPR4 antagonist 13 was developed starting from lead compound 1a. While compound 1a showed promising efficacy in several disease models, its binding to a H3 receptor as well as a hERG channel prevented it from further development. Therefore, a new round of optimization addressing the key liabilities was performed and led to discovery of compound 13 with an improved profile. Compound 13 showed significant efficacy in the rat antigen induced arthritis as well as in the hyperalgesia and angiogenesis model at a well-tolerated dose of 30 mg/kg.