2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Base Information

Chemical Name:2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
CAS No.:1421254-81-0
Molecular Formula:C₂₆H₂₈N₂O₂
Molecular Weight:400.521
Hs Code.:

Synonyms:2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Chemical Property of 2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Technology Process of 2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

There total 5 articles about 2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421254-15-0
2-(2,6-dimethylphenyl)-6-(5-isopropyl-2-methylphenyl)-4-methoxy-7,8-dihydro-1,6-naphthyridin-5(6H)-one

: 1421254-81-0
2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: With potassium trimethylsilonate; In 1,4-dioxane; at 140 ℃; for 3h; Sealed tube;

Reference yield:

: 1218994-35-4
methyl 2,4,6-trichloronicotinate

: 1421254-81-0
2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 17 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 16.5 h / 110 °C / Inert atmosphere

2.2: 4.5 h / 110 °C

3.1: acetic acid / toluene / 12 h / 110 °C

4.1: potassium trimethylsilonate / 1,4-dioxane / 3 h / 140 °C / Sealed tube

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium trimethylsilonate; sodium carbonate; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 17228-75-0
2,6-dichloro-4-methoxy pyridine

: 1421254-81-0
2-(2,6-dimethylphenyl)-4-hydroxy-6-(5-isopropyl-2-methylphenyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / toluene; tetrahydrofuran / 0.33 h / 20 °C

1.2: 0.25 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 16.5 h / 110 °C / Inert atmosphere

2.2: 4.5 h / 110 °C

3.1: acetic acid / toluene / 12 h / 110 °C

4.1: potassium trimethylsilonate / 1,4-dioxane / 3 h / 140 °C / Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; potassium trimethylsilonate; sodium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;