(+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

Base Information

Chemical Name:(+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate
CAS No.:241480-01-3
Molecular Formula:C₂₁H₂₇O₆P
Molecular Weight:406.416
Hs Code.:

Synonyms:(+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

Chemical Property:

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Technology Process of (+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

There total 3 articles about (+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26924-35-6
2-methyl-2-vinyl-1,3-dioxolane

: 241480-01-3
(+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / m-CPBA / CH₂Cl₂ / 120 h / Ambient temperature

2: 1.) n-BuLi, 2.) BF₃*OEt₂ / 1.) THF, -80 deg C, 30 min, 2.) -70 deg C, 2 h; room temperature, overnight

With n-butyllithium; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/S0968-0896(99)00065-6

Reference yield:

: 40609-93-6
(+/-)-2-(1-chloro-ethyl)-2-methyl-1,3-dioxolane

: 241480-01-3
(+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / KOH / ethane-1,2-diol / 5 h / 125 °C

2: 98 percent / m-CPBA / CH₂Cl₂ / 120 h / Ambient temperature

3: 1.) n-BuLi, 2.) BF₃*OEt₂ / 1.) THF, -80 deg C, 30 min, 2.) -70 deg C, 2 h; room temperature, overnight

With potassium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethylene glycol;
DOI:10.1016/S0968-0896(99)00065-6

Reference yield:

: 19236-58-9
dibenzyl methylphosphonate

: 241479-89-0
(+/-)-2-methyl-2-oxiranyl-1,3-dioxolane

: 241480-01-3
(+/-)-dibenzyl <3-(2-methyl-1,3-dioxolan-2-yl)-3-hydroxypropyl>-phosphonate

: {5-[2-hydroxy-2-(2-methyl-[1,3]dioxolan-2-yl)-ethoxy]-pentyl}-phosphonic acid dibenzyl ester

Guidance literature:: With n-butyllithium; boron trifluoride diethyl etherate; Yield given; Multistep reaction; 1.) THF, -80 deg C, 30 min, 2.) -70 deg C, 2 h; room temperature, overnight;
DOI:10.1016/S0968-0896(99)00065-6