Phosphonic acid, methyl-, bis(phenylmethyl) ester

Base Information

• Chemical Name: Phosphonic acid, methyl-, bis(phenylmethyl) ester
• CAS No.: 19236-58-9
• Molecular Formula: C15H17O3P
• Molecular Weight: 276.272
• DSSTox Substance ID: DTXSID70450593
• Nikkaji Number: J651.380H
• Wikidata: Q82270381
• Mol file: 19236-58-9.mol

Synonyms:19236-58-9;dibenzyl methylphosphonate;Phosphonic acid, methyl-, bis(phenylmethyl) ester;Phosphonic acid, P-methyl-, bis(phenylmethyl) ester;SCHEMBL389180;DTXSID70450593;methylphosphonic acid dibenzyl ester;[methyl(phenylmethoxy)phosphoryl]oxymethylbenzene;EN300-6489952

Chemical Property of Phosphonic acid, methyl-, bis(phenylmethyl) ester

Chemical Property:

• Boiling Point: 175 °C(Press: 0.5 Torr)
• PSA: 45.34000
• Density: 1.168±0.06 g/cm3(Predicted)
• LogP: 4.24290
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 276.09153140
• Heavy Atom Count: 19
• Complexity: 268

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CP(=O)(OCC1=CC=CC=C1)OCC2=CC=CC=C2

Technology Process of Phosphonic acid, methyl-, bis(phenylmethyl) ester

There total 15 articles about Phosphonic acid, methyl-, bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Dibenzyl phosphite (17176-77-1) + methyl iodide (74-88-4) → dibenzyl methylphosphonate (19236-58-9)

Guidance literature:

Dibenzyl phosphite; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; for 2h; Further stages.;

DOI:10.1039/b312193c

Reference yield: 94.0%

Benzyl acetate (140-11-4) + dimethyl methane phosphonate (756-79-6) → dibenzyl methylphosphonate (19236-58-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; hexane; other reagent: sodium tert-butoxide;

DOI:10.1021/jo9820521

Reference yield: 90.0%

methylphosphonic acid (993-13-5) + benzyl alcohol (100-51-6,185532-71-2) → dibenzyl methylphosphonate (19236-58-9)

Guidance literature:

With p-TsOH-Celite; at 20 ℃;

DOI:10.3184/030823407X218066

upstream raw materials:

methylphosphonic acid dichloroanhydride

benzyl alcohol

dibenzyl hydrogen phosphite

methyl iodide

Downstream raw materials:

[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid dibenzyl ester

(3-{(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid dibenzyl ester

(3-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-propyl)-phosphonic acid dibenzyl ester

Dibenzyl (3R,4S)-4-(benzyloxy)-3-hydroxypentanephosphonate