1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

Base Information

• Chemical Name: 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide
• CAS No.: 1322724-62-8
• Molecular Formula: C₂₀H₂₀ClN₅O₂S
• Molecular Weight: 429.93

Synonyms:1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

Chemical Property of 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

Chemical Property:

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Technology Process of 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

There total 2 articles about 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide (1322724-40-2) + 4-Methoxyphenyl isothiocyanate (2284-20-0) → 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1322724-62-8)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1007/s00044-011-9691-4

Reference yield:

[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-acetic acid ethyl ester (63570-02-5) → 1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1322724-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / Reflux

2: ethanol / 6 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9691-4

Reference yield: 78.0%

1-{2-[-5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1322724-62-8) → 5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-(4-methoxyphenyl)-2H-1,2,4-triazole-3-thione (1322724-82-2)

Guidance literature:

With sodium hydroxide; In ethanol; for 7h; Reflux;

DOI:10.1007/s00044-011-9691-4

upstream raw materials:

[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-acetic acid ethyl ester

2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide

4-Methoxyphenyl isothiocyanate

Downstream raw materials:

5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-(4-methoxyphenyl)-2H-1,2,4-triazole-3-thione

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