(R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

Base Information

Chemical Name:(R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate
CAS No.:133678-90-7
Molecular Formula:C₁₈H₃₀O₃Si
Molecular Weight:322.52
Hs Code.:

Synonyms:(R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

Chemical Property:

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Technology Process of (R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

There total 5 articles about (R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 127047-07-8,127047-10-3
(R)-(+)-methyl 3-hydroxy-2-methyl-2-(4-methylphenyl)propionate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 133678-90-7
(R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 40 ℃; for 0.166667h;
DOI:10.1021/jo00038a041

Reference yield:

: 79443-97-3
methyl 2-(4-methylphenyl)propanoate

: 133678-90-7
(R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 1) i-Pr₂NH, n-BuLi / 1) THF, -78 deg C, 1 h, 2) 0 deg C, 30 min

2: 95 percent / 2N NaOH / H₂O / 1 h / 25 °C / pig liver esterase, pH 7.2

3: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

4: NaBH₄ / methanol / 1 h / Ambient temperature

5: 92 percent / imidazole / dimethylformamide / 0.17 h / 40 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00038a041

Reference yield:

: 127047-04-5
dimethyl 2-methyl-2-(4-methylphenyl)malonate

: 133678-90-7
(R)-(+)-methyl 3-(tert-butyldimethylsiloxy)-2-methyl-2-(4-methylphenyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 2N NaOH / H₂O / 1 h / 25 °C / pig liver esterase, pH 7.2

2: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

3: NaBH₄ / methanol / 1 h / Ambient temperature

4: 92 percent / imidazole / dimethylformamide / 0.17 h / 40 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00038a041