9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine

Base Information

• Chemical Name: 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine
• CAS No.: 86626-10-0
• Molecular Formula: C₂₄H₂₅N₅O₅S
• Molecular Weight: 495.559
• Mol file: 86626-10-0.mol

Synonyms:9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine

Chemical Property of 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine

There total 6 articles about 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

9-(2-benzoyloxypropyl-3-hydroxy)-6-dimethylaminopurine (86626-09-7) + p-toluenesulfonyl chloride (98-59-9) → 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine (86626-10-0)

Guidance literature:

With pyridine; for 16h; Ambient temperature;

Reference yield:

6-dimethylamino-9-(3-benzyloxy-2-hydroxypropyl)purine (86626-07-5) → 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine (86626-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / triethylamine / acetonitrile / 1 h / Ambient temperature

2: 64 percent / H₂, conc. HCl / 5percent Pd/C, 20percent PdCl₂ / methanol / 3.5 h / 2327.2 Torr

3: 82 percent / pyridine / 16 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; palladium dichloride; In methanol; acetonitrile;

Reference yield:

9-(2-benzoyloxypropyl-3-benzyloxy)-6-dimethylaminopurine (86626-08-6) → 9-(2-benzoyloxypropyl-3-p-toluenesulfonyloxy)-6-dimethylaminopurine (86626-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / H₂, conc. HCl / 5percent Pd/C, 20percent PdCl₂ / methanol / 3.5 h / 2327.2 Torr

2: 82 percent / pyridine / 16 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; palladium dichloride; In methanol;

upstream raw materials:

9-(2-benzoyloxypropyl-3-hydroxy)-6-dimethylaminopurine

p-toluenesulfonyl chloride

6-dimethylamino-9-(3-benzyloxy-2-hydroxypropyl)purine

9-(2-benzoyloxypropyl-3-benzyloxy)-6-dimethylaminopurine

Downstream raw materials:

9-(3-azido-2-benzoyloxypropyl)-6-dimethylaminopurine

9-(3-amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride