3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Base Information

Chemical Name:3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine
CAS No.:364048-15-7
Molecular Formula:C₅₀H₄₆N₉O₁₄P
Molecular Weight:1027.94
Hs Code.:

Synonyms:3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

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Chemical Property of 3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Chemical Property:

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Technology Process of 3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

There total 5 articles about 3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₁₂N₃O₂N₃C₇H₄OHCOCH₂ONHC₁₅H₁₀O₂PO₂(C₂H₄C₆H₄NO₂)2

: 364048-15-7
3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -35 ℃; for 1h;
DOI:10.1021/ol0162217

Reference yield:

: 74625-78-8
5'-azido-N⁶-benzoyl-2',5'-dideoxy-adenosine

: 364048-15-7
3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂; acetic acid / Pd/C / methanol / 3 h

2.1: EEDQ / dimethylformamide / 0.5 h / 20 °C

2.2: 61 percent / dimethylformamide / 2.5 h

3.1: tetrazole / CH₂Cl₂ / 6 h / 20 °C

4.1: 454 mg / mCPBA / CH₂Cl₂ / 1 h / -35 °C

With 1H-tetrazole; hydrogen; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0162217

Reference yield:

: 102690-87-9
bis(2-<4-nitrophenyl>ethyl) N,N-diisopropylphosphoramidite

: 364048-15-7
3'-[[bis[2-(4-nitrophenyl)ethoxy]phosphinyl]oxy]-5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / CH₂Cl₂ / 6 h / 20 °C

2: 454 mg / mCPBA / CH₂Cl₂ / 1 h / -35 °C

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/ol0162217