5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Base Information

Chemical Name:5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine
CAS No.:364048-14-6
Molecular Formula:C₃₄H₃₁N₇O₇
Molecular Weight:649.663
Hs Code.:

Synonyms:5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

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Chemical Property of 5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

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Technology Process of 5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

There total 2 articles about 5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 289884-72-6
N-[9-(5-aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide

: 123106-21-8
2-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)oxy)acetic acid

: 364048-14-6
5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Guidance literature:: 2-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)oxy)acetic acid; With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-[9-(5-aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide; In N,N-dimethyl-formamide; for 2.5h; Further stages.;
DOI:10.1021/ol0162217

Reference yield:

: 74625-78-8
5'-azido-N⁶-benzoyl-2',5'-dideoxy-adenosine

: 364048-14-6
5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂; acetic acid / Pd/C / methanol / 3 h

2.1: EEDQ / dimethylformamide / 0.5 h / 20 °C

2.2: 61 percent / dimethylformamide / 2.5 h

With hydrogen; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol0162217