N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Base Information

Chemical Name:N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine
CAS No.:98688-15-4
Molecular Formula:C₄₅H₆₄N₆O₁₃
Molecular Weight:897.036
Hs Code.:

Synonyms:N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Suppliers and Price of N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

There total 4 articles about N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6041-34-5
<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-L-threonyl-D-valyl-L-prolyl-sarcosine tert-butyl ester

: 16948-16-6
tert-butoxycarbonyl-N-methyl-L-alanine

: 98688-15-4
N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 26 ℃; for 16h;
DOI:10.1021/ja00310a065

Reference yield:

: 27483-27-8
N-(benzyloxycarbonyl)-D-valylprolylsarcosine tert-butyl ester

: 98688-15-4
N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-cyclohexadiene / 10percent palladium/charcoal / ethanol

2: HONB/DCC / dimethylformamide / 48 h / -5 °C

3: 81 percent / DMAP/DCC / CH₂Cl₂ / 16 h / 26 °C

With dmap; cyclohexa-1,4-diene; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00310a065

Reference yield:

: 2441-62-5
<3-(benzyloxy)-4-methyl-2-nitro-benzoyl>-L-threonine

: 98688-15-4
N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-alalnyl)-L-threonyl-D-valyl-L-prolylsarcosine

Guidance literature:: Multi-step reaction with 2 steps

1: HONB/DCC / dimethylformamide / 48 h / -5 °C

2: 81 percent / DMAP/DCC / CH₂Cl₂ / 16 h / 26 °C

With dmap; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00310a065