((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

Base Information

Chemical Name:((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane
CAS No.:1448888-95-6
Molecular Formula:C₂₂H₂₆BrIO₄Si
Molecular Weight:589.34
Hs Code.:

Synonyms:((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

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Chemical Property of ((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

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Technology Process of ((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

There total 5 articles about ((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1448888-87-6
4-(bromomethyl)-5-iodobenzo[d][1,3]dioxole

: 1448888-93-4
(Z)-2-bromo-6-methoxy-3-(4-(trimethylsilyl)but-2-en-1-yl)phenol

: 1448888-95-6
((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 5h; Inert atmosphere;
DOI:10.1002/anie.201209868

Reference yield:

: 5876-51-7
5-iodo-1,3-benzodioxole

: 1448888-95-6
((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 18 h / -78 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 0 - 20 °C / Inert atmosphere

3.1: phosphorus tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 5 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201209868

Reference yield:

: 249636-72-4
5-iodobenzo[d][1,3]dioxole-4-carbaldehyde

: 1448888-95-6
((Z)-4-(2-bromo-3-((5-iodobenzo[d][1,3]dioxol-4-yl)methoxy)-4-methoxyphenyl)but-2-en-1-yl)trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 5 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; In ethanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201209868