(S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate
CAS No.:1394169-81-3
Molecular Formula:C₂₃H₃₃N₃O₄
Molecular Weight:415.533
Hs Code.:

Synonyms:(S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

There total 2 articles about (S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444002-68-0
1-(4-(methylamino)phenyl)piperidin-2-one

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1394169-81-3
(S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield:

: 675-20-7
piperidin-2-one

: 1394169-81-3
(S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / toluene / Inert atmosphere; Reflux

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N`-dimethylethylenediamine; In dichloromethane; toluene;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield: 100.0%

: 1394169-81-3
(S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate

: 1394170-08-1
C₁₈H₂₅N₃O₂

Guidance literature:: (S)-tert-butyl 2-(methyl(4-(2-oxopiperidin-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃;
DOI:10.1016/j.ejmech.2012.06.032