(E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine

Base Information

• Chemical Name: (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine
• CAS No.: 77415-95-3
• Molecular Formula: C₂₁H₂₉NO₂
• Molecular Weight: 327.467
• Mol file: 77415-95-3.mol

Synonyms:(E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine

Chemical Property of (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine

There total 4 articles about (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodophencyclidine (77415-80-6) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (Z)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine (77415-96-4) + (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine (77415-95-3)

Guidance literature:

With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In acetonitrile; at 100 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00326a033

Reference yield:

1-piperidinocyclohexylcarbonitrile (3867-15-0) → (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine (77415-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, 2.) / 1.) ether, benzene, reflux, 2.) reflux, 4 h

2: triethylamine, tri-o-tolylphosphine / palladium acetate / acetonitrile / 100 °C

With magnesium; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In acetonitrile;

DOI:10.1021/jo00326a033

Reference yield:

4-Bromophencyclidine (2201-33-4) → (E)-4-<1-<2-(Carbomethoxy)ethenyl>>phencyclidine (77415-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) butyllithium, 2.) iodine / 1.) THF, -78 deg C, 2.)

2: triethylamine, tri-o-tolylphosphine / palladium acetate / acetonitrile / 100 °C

With n-butyllithium; iodine; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In acetonitrile;

DOI:10.1021/jo00326a033

upstream raw materials:

4-iodophencyclidine

acrylic acid methyl ester

1-piperidinocyclohexylcarbonitrile

4-Bromophencyclidine

Refernces