(Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester

Base Information

• Chemical Name: (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester
• CAS No.: 505030-55-7
• Molecular Formula: C₁₇H₂₃NO₃
• Molecular Weight: 289.375
• Mol file: 505030-55-7.mol

Synonyms:(Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester

Chemical Property of (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester

There total 3 articles about (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Methyl 3-acetoxy-2-methylene-3-phenylpropanoate (124957-36-4) + piperidin-2-ylmethanol (3433-37-2) → (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester (505030-55-7)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1055/s-2002-34843

Reference yield:

methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) → (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester (505030-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 4 h / 0 °C

2: 94 percent / K₂CO₃ / CH₂Cl₂ / 10 h / 20 °C

With pyridine; potassium carbonate; In dichloromethane;

DOI:10.1055/s-2002-34843

Reference yield:

benzaldehyde (100-52-7) → (Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid methyl ester (505030-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: DABCO / ethyl acetate / 168 h

2: pyridine / CH₂Cl₂ / 4 h / 0 °C

3: 94 percent / K₂CO₃ / CH₂Cl₂ / 10 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; In dichloromethane; ethyl acetate; 1: Baylis-Hillman reaction;

DOI:10.1055/s-2002-34843

upstream raw materials:

Methyl 3-acetoxy-2-methylene-3-phenylpropanoate

piperidin-2-ylmethanol

methyl 3-hydroxy-2-methylidene-3-phenylpropionate

benzaldehyde

Downstream raw materials:

(Z)-2-(2-Hydroxymethyl-piperidin-1-ylmethyl)-3-phenyl-acrylic acid