3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

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Chemical Name:3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione
CAS No.:714272-33-0
Molecular Formula:C₂₁H₂₄N₄O₄
Molecular Weight:396.446
Hs Code.:

Synonyms:3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

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Chemical Property of 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

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Technology Process of 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

There total 4 articles about 3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 714273-83-3
5-(tert-butyl)-1H-imidazole-4-carbaldehyde

: 714272-33-0
3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm2009088

Reference yield:

: 714273-89-9
5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester

: 714272-33-0
3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 14 h / 165 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3: manganese(IV) oxide / acetone / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm2009088

Reference yield:

: 51721-21-2
5-(tert-butyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 714272-33-0
3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-6-[(Z)-1-(2,4-dimethoxyphenyl)methylidene]-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / acetone / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm2009088