Ethyl 5-tert-butyl-1,3-oxazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 5-tert-butyl-1,3-oxazole-4-carboxylate
• CAS No.: 714273-89-9
• Molecular Formula: C10H15NO3
• Molecular Weight: 197.234
• Hs Code.: 2934999090
• Mol file: 714273-89-9.mol

Synonyms:Ethyl 5-tert-butyl-1,3-oxazole-4-carboxylate;4-Oxazolecarboxylic acid, 5-(1,1-dimethylethyl)-, ethyl ester

Chemical Property of Ethyl 5-tert-butyl-1,3-oxazole-4-carboxylate

Chemical Property:

• PSA: 52.33000
• LogP: 2.14880

Purity/Quality:

97% ^*data from raw suppliers

ethyl5-tert-butyl-1,3-oxazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-tert-butyl-1,3-oxazole-4-carboxylate

There total 5 articles about Ethyl 5-tert-butyl-1,3-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Ethyl isocyanoacetate (2999-46-4) + 2,2-dimethylpropanoic anhydride (1538-75-6) → 5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester (714273-89-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 4 - 20 ℃;

Reference yield: 99.0%

Ethyl isocyanoacetate (2999-46-4) → 5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester (714273-89-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; Product distribution / selectivity;

Reference yield: 89.0%

Ethyl isocyanoacetate (2999-46-4) + Trimethylacetic acid (75-98-9) → 5-(tert-butyl)oxazole-4-carboxylic acid ethyl ester (714273-89-9)

Guidance literature:

Trimethylacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 55 ℃; for 1h;

Ethyl isocyanoacetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1007/s10593-019-02475-9

upstream raw materials:

2-chloro-4,4-dimethyl-3-oxopentanoic acid ethyl ester

formamide

Ethyl isocyanoacetate

2,2-dimethylpropanoic anhydride

Downstream raw materials:

5-tert-butyl-4-oxazolecarboxaldehyde

3-{(Z)-1-[5-(tert-butyl)-1H-4-oxazolyl]methylidene}-6-[(Z)-1-(phenyl)methylidene]-2,5-piperazinedione

3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

3-{(Z)-1-[5-(tert-butyl)-1H-4-oxazolyl]methylidene}-6-[(Z)-1-(3-methoxyphenyl)methylidene]-2,5-piperazinedione

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