Technology Process of C11H11F2NO2
There total 6 articles about C11H11F2NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethylamino-sulfur trifluoride / 24 h / 23 °C / Inert atmosphere
2: potassium trimethylsilonate / diethyl ether / 12 h / 23 °C / Inert atmosphere
3: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0 - 100 °C / Inert atmosphere
4: sodium azide / water; acetone / 1 h / 0 °C / Inert atmosphere
5: toluene / 1 h / 100 °C / Inert atmosphere
6: toluene / 3 h / 95 °C / Inert atmosphere
With
thionyl chloride; sodium azide; diethylamino-sulfur trifluoride; potassium trimethylsilonate;
In
diethyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja108347d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0 - 100 °C / Inert atmosphere
2: sodium azide / water; acetone / 1 h / 0 °C / Inert atmosphere
3: toluene / 1 h / 100 °C / Inert atmosphere
4: toluene / 3 h / 95 °C / Inert atmosphere
With
thionyl chloride; sodium azide;
In
water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja108347d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium azide / water; acetone / 1 h / 0 °C / Inert atmosphere
2: toluene / 1 h / 100 °C / Inert atmosphere
3: toluene / 3 h / 95 °C / Inert atmosphere
With
sodium azide;
In
water; acetone; toluene;
DOI:10.1021/ja108347d
