benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate

Base Information

• Chemical Name: benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate
• CAS No.: 1168-86-1
• Molecular Formula: C₁₇H₁₇N₃O₅
• Molecular Weight: 343.339
• Mol file: 1168-86-1.mol

Synonyms:benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate

Chemical Property of benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate

There total 2 articles about benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-nitro-aniline (100-01-6,104810-17-5) + benzyl N-[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]carbamate (820239-42-7) → benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate (1168-86-1)

Guidance literature:

In water; at 50 ℃; for 0.25h; Microwave irradiation; Green chemistry;

DOI:10.3390/molecules25112501

Reference yield:

N-Cbz-Ala (1142-20-7) + 4-nitro-aniline (100-01-6,104810-17-5) → benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate (1168-86-1)

Guidance literature:

N-Cbz-Ala; 4-nitro-aniline; In ethyl acetate;

With dicyclohexyl-carbodiimide; In ethyl acetate; at 20 ℃;

DOI:10.1016/j.molcata.2016.01.029

Reference yield:

benzyl (S)-(1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)carbamate (1168-86-1) → L-alanine-p-nitroanilide (1668-13-9,26017-82-3,26432-41-7,77286-89-6)

Guidance literature:

With hydrogen bromide; In acetic acid;

DOI:10.1248/cpb.30.4060

upstream raw materials:

N-Cbz-Ala

4-nitro-aniline

benzyl N-[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]carbamate

Downstream raw materials:

L-alanine-p-nitroanilide

H-Val-Ala-Ala-pNA

N-Boc-L-Leu-L-Ala-pNA

Z-Val-Ala-pNA