7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

Base Information

• Chemical Name: 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one
• CAS No.: 1620884-16-3
• Molecular Formula: C₂₆H₂₅BrClN₃O
• Molecular Weight: 510.861
• Mol file: 1620884-16-3.mol

Synonyms:7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

Chemical Property of 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one

There total 3 articles about 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt (1620885-30-4) + (1-bromoethyl)benzne (585-71-7,38661-81-3) → 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-16-3)

Guidance literature:

With caesium carbonate; In acetonitrile; at 50 ℃; for 2h;

Reference yield:

2-amino-4-bromobenzoic acid (20776-50-5) → 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-16-3)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1 h / 80 °C

2: pyridine / dichloromethane / 1 h / 0 - 20 °C

3: toluene / 1 h / 140 °C

4: caesium carbonate / acetonitrile / 2 h / 50 °C

With pyridine; thionyl chloride; caesium carbonate; N,N-dimethyl-formamide; In dichloromethane; toluene; acetonitrile;

Reference yield:

C7H5BrClNO (1261666-37-8) → 7’-bromo-3’-(4-chlorophenyl)-1-(1-phenylethyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one (1620884-16-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: toluene / 1 h / 140 °C

3: caesium carbonate / acetonitrile / 2 h / 50 °C

With pyridine; caesium carbonate; In dichloromethane; toluene; acetonitrile;

upstream raw materials:

7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

(1-bromoethyl)benzne

C₇H₅BrClNO

2-amino-4-bromobenzoic acid