7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

Base Information

Chemical Name:7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt
CAS No.:1620885-30-4
Molecular Formula:C₇H₈O₃S*C₁₈H₁₇BrClN₃O
Molecular Weight:578.914
Hs Code.:

Synonyms:7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

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Chemical Property of 7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

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Technology Process of 7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

There total 3 articles about 7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1520676-50-9
2-amino-4-bromo-N-(4-chlorophenyl)benzamide

: 6192-52-5
p-toluenesulfonic acid monohydrate

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1620885-30-4
7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

Guidance literature:: In toluene; at 140 ℃; for 1h;

Reference yield:

: 1261666-37-8
C₇H₅BrClNO

: 1620885-30-4
7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: toluene / 1 h / 140 °C

With pyridine; In dichloromethane; toluene;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1620885-30-4
7’-bromo-3’-(4-chlorophenyl)-1‘H-spiro[piperidine-4,2’-quinazolin]-4’(3’H)-one tosylate salt

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1 h / 80 °C

2: pyridine / dichloromethane / 1 h / 0 - 20 °C

3: toluene / 1 h / 140 °C

With pyridine; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene;