tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

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Chemical Name:tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate
CAS No.:252279-41-7
Molecular Formula:C₂₄H₂₅N₃O₂S
Molecular Weight:419.547
Hs Code.:

Synonyms:tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

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Chemical Property of tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

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Technology Process of tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

There total 3 articles about tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 70-11-1
α-bromoacetophenone

: 252279-30-4
tert-butyl (R)-(1-amino-3-(1H-indol-3-yl)-1-thioxopropan-2-yl)carbamate

: 252279-41-7
tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

Guidance literature:: at 90 ℃; for 0.166667h;
DOI:10.1021/jm0108449

Reference yield:

: 151872-21-8
(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid methyl ester

: 252279-41-7
tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NH₃(g) / methanol / 24 h / 85 °C

2: P₂S₅; NaHCO₃ / 1,2-dimethoxy-ethane

3: 38 percent / 0.17 h / 90 °C

With tetraphosphorus decasulfide; ammonia; sodium hydrogencarbonate; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/jm0108449

Reference yield:

: 5241-64-5
Boc-D-Trp-OH

: 252279-41-7
tert-butyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1,3-thiazol-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / 1,2-dimethoxyethane / 0.03 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; tetraphosphorus decasulfide / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

3.1: ethanol / 20 °C / Inert atmosphere

With 4-methyl-morpholine; tetraphosphorus decasulfide; sodium hydrogencarbonate; isobutyl chloroformate; In 1,2-dimethoxyethane; ethanol;
DOI:10.1002/cmdc.201600248