N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Base Information

Chemical Name:N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide
CAS No.:1092394-96-1
Molecular Formula:C₂₄H₂₁N₅O₂
Molecular Weight:411.463
Hs Code.:

Synonyms:N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

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Chemical Property of N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

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Technology Process of N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

There total 9 articles about N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1092393-62-8
N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

: 1092394-96-1
N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: With water; sodium hydroxide; In ethanol; at 45 ℃; for 12h;
DOI:10.1021/jm300126x

Reference yield:

: 872091-85-5
methyl 3-(1-cyano-1-methylethyl)benzoate

: 1092394-96-1
N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 18 h / 20 °C

2.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 4 - 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

4.1: pyridine / 48 h / 80 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 48 h / 20 °C

6.1: dichloromethane / 16 h / 20 °C

7.1: water; sodium hydroxide / ethanol / 12 h / 45 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1092394-96-1
N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-(1-cyano-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol; ethyl acetate / 20 h / 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

4.1: pyridine / 48 h / 80 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 48 h / 20 °C

6.1: dichloromethane / 16 h / 20 °C

7.1: water; sodium hydroxide / ethanol / 12 h / 45 °C

With pyridine; palladium 10% on activated carbon; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x