(E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide
• CAS No.: 1442433-66-0
• Molecular Formula: C₁₉H₂₃NO₃S
• Molecular Weight: 345.463
• Mol file: 1442433-66-0.mol

Synonyms:(E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide

Chemical Property of (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide

There total 3 articles about (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-5-(4-methoxyphenyl)pent-4-en-1-amine (1442433-54-6) + p-toluenesulfonyl chloride (98-59-9) → (Z)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide + (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide (1442433-66-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Overall yield = 25 %; Inert atmosphere;

DOI:10.1021/ja4031616

Reference yield:

toluene-4-sulfonamide (70-55-3) + (E)-5-(4-methoxyphenyl)pent-4-enyl methanesulfonate (197707-43-0) → (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide (1442433-66-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja5046296

Reference yield:

(4E)-5-(4-methoxyphenyl)pent-4-en-1-ol (105401-84-1,148020-19-3,76978-39-7) → (E)-N-(5-(4-methoxyphenyl)pent-4-en-1-yl)-4-methylbenzenesulfonamide (1442433-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Schlenk technique; Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja5046296

upstream raw materials:

(E)-5-(4-methoxyphenyl)pent-4-en-1-amine

p-toluenesulfonyl chloride

(4E)-5-(4-methoxyphenyl)pent-4-en-1-ol

toluene-4-sulfonamide

Downstream raw materials:

2-(4-methoxybenzyl)-1-(toluene-4-sulfonyl)pyrrolidine

(2S,3R)-N-(4-toluenesulfonyl)-2-(4-methoxyphenyl)-3-(phenylthio)piperidine