(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate

Base Information

• Chemical Name: (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS No.: 1512860-68-2
• Molecular Formula: C₃₇H₃₄N₄O₇
• Molecular Weight: 646.7
• Mol file: 1512860-68-2.mol

Synonyms:(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property of (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate

There total 2 articles about (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine (79366-24-8) + cyclohexane (110-82-7,25012-93-5) → (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate (1512860-68-2)

Guidance literature:

With di-tert-butyl peroxide; at 140 ℃; for 2h; Sealed tube;

DOI:10.1039/c6ob00596a

Reference yield: 78.0%

9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine (79366-24-8) + Cyclohexanecarboxylic acid (98-89-5) → (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(6-cyclohexyl-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate (1512860-68-2)

Guidance literature:

With ammonium peroxydisulfate; silver nitrate; In dichloromethane; water; at 20 ℃; for 24h; regioselective reaction;

DOI:10.1021/ol4033336

upstream raw materials:

9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine

Cyclohexanecarboxylic acid

cyclohexane