ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate

Base Information

• Chemical Name: ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate
• CAS No.: 1001387-70-7
• Molecular Formula: C₂₆H₂₆ClNO₆
• Molecular Weight: 483.949
• Mol file: 1001387-70-7.mol

Synonyms:ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate

Chemical Property of ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate

There total 1 articles about ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

{5-Chloro-2-[3-(dimethoxymethyl)-5-isopropylisoxazol-4-yl]phenyl}(2,3-dimethoxyphenyl)-methanone (1001387-69-4) + ethoxycarbonylmethyltriphenylphosphorane → ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate (1001387-70-7)

Guidance literature:

{5-Chloro-2-[3-(dimethoxymethyl)-5-isopropylisoxazol-4-yl]phenyl}(2,3-dimethoxyphenyl)-methanone; With hydrogenchloride; water; In tetrahydrofuran; for 42h; Reflux;

ethoxycarbonylmethyltriphenylphosphorane; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 36.0%

ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate (1001387-70-7) → ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate (1314186-06-5)

Guidance literature:

ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate; With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

With 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); In tetrahydrofuran; at 0 ℃; for 1h;

upstream raw materials:

{5-Chloro-2-[3-(dimethoxymethyl)-5-isopropylisoxazol-4-yl]phenyl}(2,3-dimethoxyphenyl)-methanone

Downstream raw materials:

ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate