ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

Base Information

Chemical Name:ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate
CAS No.:1314186-06-5
Molecular Formula:C₂₆H₂₈ClNO₆
Molecular Weight:485.964
Hs Code.:

Synonyms:ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

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Chemical Property of ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

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Technology Process of ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

There total 12 articles about ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1001387-70-7
ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate

: 1314186-06-5
ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

Guidance literature:: ethyl (2E)-3-{4-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-5-isopropylisoxazol-3-yl}acrylate; With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

With 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: C₂₆H₂₈ClNO₆

: 1314186-06-5
ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

Guidance literature:: With 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); In tetrahydrofuran; at 0 ℃; for 1h; optical yield given as %de;
DOI:10.1016/j.bmcl.2011.04.092

Reference yield:

: 2-(3-methyl-1-butyn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1314186-06-5
ethyl [8-chloro-6-(2,3-dimethoxyphenyl)-1-isopropyl-4H,6H-[2]benzoxepino[4,5-c]isoxazol-4-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 56 h / 50 °C

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dichloromethane / 72 h / 85 °C

3: hydrogenchloride / tetrahydrofuran; water / 42 h / Reflux

4: dichloromethane / 16 h / 20 °C

5: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / 0 °C

6: 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene) / tetrahydrofuran / 1 h / 0 °C

With hydrogenchloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium hydrogencarbonate; 1-tert-butyl-2,2,4,4,4-pentakis(dimethylamino)-2Λ⁵,4Λ⁵-catenadi(phosphazene); lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki coupling / 4: Wittig olefination;
DOI:10.1016/j.bmcl.2011.04.092