(R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

Base Information

Chemical Name:(R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether
CAS No.:172546-95-1
Molecular Formula:C₂₆H₄₂F₂O₄S₂Si
Molecular Weight:548.831
Hs Code.:

Synonyms:(R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

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Chemical Property of (R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

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Technology Process of (R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

There total 6 articles about (R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 172547-01-2
(4-hydroxy-3-methoxyphenyl)ethylaldehyde propanedithioacetal

: 172546-94-0
(R)-(+)-ethyl 2,2-difluoro-3-(t-butyldimethylsilyloxy)octanoate

: 172546-95-1
(R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h;
DOI:10.1016/0040-4020(95)00868-9

Reference yield:

: 97-53-0
4-allylguaiacol

: 172546-95-1
(R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ozone gas, NaHCO₃; 2.) dimethylsulfide / 1.) MeOH/CH₂Cl₂, -78 deg C, 1.5 h; 2.) MeOH/CH₂Cl₂, rt

2: 81 percent / boron trifluoride etherate / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 49 percent / 1.) n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h

With n-butyllithium; dimethylsulfide; boron trifluoride diethyl etherate; sodium hydrogencarbonate; ozone; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/0040-4020(95)00868-9

Reference yield:

: 5703-24-2
2-(4-hydroxy-3-methoxyphenyl)acetaldehyde

: 172546-95-1
(R)-(-)-<6>-2,2-difluoro-4,4-(1,3-propanedithioacetyl)gingerol-t-butyldimethylsilylether

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / boron trifluoride etherate / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 49 percent / 1.) n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min; 2.) -78 deg C, 1 h

With n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/0040-4020(95)00868-9