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GMP Standard Manufacturer Supply Lilac Extract CAS NO.97-53-0
Cas No: 97-53-0
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Syzygium aromaticum Extract
Cas No: 97-53-0
USD $ 12.0-12.0 / Kilogram 1 Kilogram 300 Kilogram/Month Greenutra Resource Inc Contact Supplier
High quality Eugenol supplier in China
Cas No: 97-53-0
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Top purity Eugenol with high quality and best price cas:97-53-0
Cas No: 97-53-0
USD $ 2.0-5.0 / Gram 1 Gram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Eugenol Cas 97-53-0 with factory best price
Cas No: 97-53-0
USD $ 33.0-35.0 / Kilogram 25 Kilogram 100 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Fresh In Stock:2-Methoxy-4-(2-propenyl)phenol with BEST PRICE
Cas No: 97-53-0
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Scale Chemical Corporation Contact Supplier
Cas No: 97-53-0
No Data 1 Kilogram 20 Metric Ton/Quarter Henan Allgreen Chemical Co.,Ltd Contact Supplier
Cas No: 97-53-0
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Cas No: 97-53-0
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
High purity Eugenol 98% TOP1 supplier in China
Cas No: 97-53-0
USD $ 1.0-2.0 / Gram 100 Gram 1-1000 Metric Ton/Day Hangzhou Dayangchem Co., Ltd. Contact Supplier

97-53-0 Usage

General Description

Clear colorless pale yellow or amber-colored liquid. Odor of cloves. Spicy pungent taste.

Contact allergens

Eugenol is a fragrance allergen obtained from many natural sources. Occupational sensitization to eugenol may occur in dental profession workers. Eugenol is contained in “fragrance mix” and has to be listed by name in cosmetics within the EU.

Reactivity Profile

Eugenol is incompatible with strong oxidizers. This includes ferric chloride and potassium permanganate. Eugenol reacts with strong alkalis. Eugenol is incompatible with iron and zinc.


ChEBI: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group.


ADI 0~2.5 (FAO/WHO, 1994)
LD50 1930~2680mg/kg (rat, oral)
GRAS (FDA $ 184.1257, 2000

Content analysis

Method 1: gas chromatography (GT-10-4) with non-polar column. The content is determined by area percentage.
Method 2: According to determination of phenol (OT-37). It was placed in the water bath for 30 minutes with heating, and cooled at room temperature.


Eugenol exists naturally in eugenia oil, basil oil and cinnamon oil and other essential oils. It is a thick oily liquid, colorless to pale yellow, with a strong aroma of clove and a pungent aroma.
At present, most of the industries deal with essential oils rich in eugenol with alkali to produce eugenol. The sodium hydroxide solution is usually added to the separated oil, and then the mixture is heated and stirred. The oil of the non-phenol part floating on the liquid surface is extracted with a solvent, and it could be steamed off also. Add acid to acidify sodium salt to obtain crude eugenol, and then wash with water to neutral state, and finally distill in vacuum to get pure eugenol.
formula of Eugenol

Fire Hazard

Eugenol is combustible.

Physical and chemical properties

The scientific name for eugenol is 4-allyl-2-methoxyphenol. Some data about it are as follows: molecular formula C10H12O2; molecular weight 164.21; boiling point 253 ℃; melting point-9.2 ~-9.1℃; relative density d2525 1.053~1.064; refractive index nD20 1.538~1.542. It is miscible with alcohol, ether, chloroform and volatile oil. What’s more, it is slightly soluble in water, and soluble in acetic acid and caustic solution. It gradually darkens and thickens in the air. Iron, zinc and other metal ions could catalyze its oxidation. So we should store it below 25 ℃, and protect it from light. Eugenol could make the red litmus and ferric chloride ethanol solution blue. It is present in the clove oil (90%), clove basil oil (about 60%), violet flower oil (about 20%), cinnamon leaf oil, lauric oil, camphor oil, acacia oil and citronella oil. It can be used as fixative and modifier for woody and oriental essence in the spice. It is the main essence for preparation of clove and carnation flavor. It is also often used in the mint, nut and spicy food flavor and tobacco flavor. It can also be used to synthesize vanillin. It is applied for medical and health products and dental hygiene. Eugenol is available in the United States FEMA2467, and it is approved for food by US FDA.

Chemical Properties

colourless to faintly yellow liquid with a strong odour of cloves


Clove tree is a variant name for lilac. It is bud of Syzygium Myrtaceous plant. There are more than 500 kinds of Syzygium in the world, about 72 species in China.
Clove is a tropical and humid forest plant. The growth environment should be warm and humid, and should not be cold. Uniform and abundant rain is needed. In addition, deep, fertile and well-drained soil is better. It can be harvested when the buds turn from green to red in September to March of the following year. After it is harvested, we should remove the pedicel and dry it.
The bud is nail-shaped, and the length is 1~2cm. Calyx tube is cylindrical and slightly quadrangular, with the length of 6~14mm, diameter of about 5mm. The base gradually becomes narrow. And rough surface engraved seepage oil. The upper part has 4triangular sepals that are reddish brown or dark brown and the length is about 3mm. The top corolla is round, with diameter of 4 to 6 mm. 4 tan petals wrap around in tiles. Cut open buds, we could see the situation: a lot of stamens; filaments bent to the center; the central has a straight sturdy which is easy to sink in the water. The section is oily. It has a strong aroma and spicy taste, with a sense of hemp. Lilac is better with these characteristics: large, stout, fresh purple brown, strong aroma, more oil. There are volatile oil 16~19% in buds. The main oil contained in volatile oil are eugenol 80~87%, β-clove 9%, aceto-eugenol7%. In addition, some trace components are present, for example, heptanone-2, methyl salicylate, α-clove Benzene, Benzaldehyde, Benzyl Alcohol, Benzyl Acetate, Methoxybenzaldehyde, Yulanene, and Piperin.
Clove has an antibacterial effect. Ether extract of clove with 1% concentration, water immersion or decoction of Saboura's medium of clove with 8% concentration could inhibit the trichophyton schoenleinii, candida albicans and other pathogenic fungi. Clove oil and eugenol have a strong inhibition on the brucellosis, mycobacterium tuberculosis in the test tube. Clove oil and eugenol also have significant inhibitory effects on common pathogenic fungi. Clove oil and eugenol have antibacterial effect on the staphylococcus aureus, pneumonia, dysentery, large intestine, deformation and other bacteriat with the concentration 1: 2000~1: 8000.
Picture of lilac
Picture of lilac

Air & Water Reactions

Darkens and thickens on exposure to air. Also darkens with age. Eugenol may decompose on exposure to light. Insoluble in water.

Purification Methods

Fractional distillation of eugenol gives a pale yellow liquid which darkens and thickens on exposure to air. It should be stored under N2 at -20o. [Waterman & Priedster Recl Trav Chim Pays-Bas 48 1272 1929, Beilstein 6 H 961, 6 IV 6337.]


Eugenol can be isolated from natural essential oils, also be synthesized by chemical method in industry. However, chemical synthesis method produces isomers. Boiling point of two isomers is very close, resulting in difficult separation. So isolation method is the main method at present.
Isolation method from natural essential oil:
Take perennial sub-shrub clove basil as raw material, we get the mixture of essential oil and water through steam distillation. Add 20% of sodium hydroxide into the mixture, and then distill with steam to remove non-acidic substances. The resulting solution of sodium eugenol is added to 30% sulfuric acid at 50 ° C and stirred to pH = 2~3 (water layer). After standing, separate the lower layer of lilac oil, and then we get eugenol product through reduced pressure distillation.


Eugenol is a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.

Stimulate data

Skin-Rabbit 100 mg/24 h     severe


blood volume expander

Toxic grading

Moderate toxicity

Extinguishing agent

Dry powder, foam, sand.

Use limit

FEMA (mg/kg): soft drink 1.4; cold drink 3.1 0 candy 32; baked goods 33, pudding 0.60; chewing gum 500.



Storage characteristics

Ventilated warehouse, low temperature, dry; separated from food materials


Guaiacol is used as raw material. Allyl chloride and allyl alcohol have a direct effect of allylation on guaiacol (patent in the former Soviet Union 352872; US patent 3929904).
There are some disadvantages of synthetic method in making eugenol. These shortcomings need to be improved in the future. Disadvantages are as follows: Many side effects result in difficult separation and purification, and they also affect the quality of product.
Eugenol is used in the formula of perfume essence, a variety of cosmetic essence and soap essence, with the amount of less than 20%. It can also be used in food flavors. There is no restriction in IFRA.
Structural formula of Eugenol


Eugenin is naturally present in essential oils such as ylang ylang oil, Tuberose, jonquil oil and calamus oil. Eugenin is heavy with scent of flowers and clove. It has two isomers. The trans-isomer has a melting point of 33~ 34 ° C, and a boiling point of 140 ° C/1.6 Kpa, 118 ° C/670 Pa. The cis-isomer is a liquid having a boiling point of 115 ° C/670 Pa and 98 ° C/130 Pa. The product is a mixture of cis-isomer and trans-isomer, of with the majority is trans-isomers. The ratio of trans-isomer and cis-isomer is about 85:15, and the freezing point is about 12 ℃. According to the information provided by RIFM, the acute toxicity data of eugenol: Oral LD501.56 g/kg (rat), 1.41 g/kg (guinea pig). Cis-isomer has a LD50 of 0.365 g/kg and a trans-form of 0.54 g/kg. The highest doses of cis-isomer and trans-form which did not cause death are 0.10 g/kg and 0.20 g/kg respectively, and the lowest doses which cause death of all animals are 0.60 g/kg and 0.80 g/kg respectively.
Eugenin can be widely used in cosmetics and soaps and flavors. However, allergy is present if the concentration of Eugenin is too high, so IFRA prescribes a maximum concentration with 1% in the essence formula, no more than 0.2% in consumer products, and no more than 0.5% in consumer products that are not in contact with the skin.

Chemical synthesis

Allyl bromide, o-methoxyphenol, anhydrous acetone and anhydrous potassium carbonate are added to the kettle and heated to reflux for several hours. After cooling, dilute with water and then extract with ether. The extract is washed with 10% sodium hydroxide and dried over anhydrous potassium carbonate. Recover diethyl ether and acetone after distillation at atmospheric pressure, and then distill under reduced pressure and collect fraction at 110~113 ℃ (1600Pa), finally we get o-methoxyphenyl allyl ether. The mixture is boiled and refluxed for 1 hour and then cooled. The resulting grease is dissolved in ether and extracted with 10% sodium hydroxide solution. The extract is acidified with hydrochloric acid and extracted with ether. Dry the extract over anhydrous sodium sulfate and recover the ether through air distillation, and finally we get product. We could also get product through one step reaction between o-methoxyphenol and allyl chloride with copper as catalyst at 100 ℃.
Take essential oils containing large amounts of eugenol, such as clove oil, as raw materials, and add 30% sodium hydroxide solution, and then add inorganic acid or carbon dioxide to precipitate. In addition, addition reaction between clove oil and sodium acetate is also available.
Eugenol could be prepared by synthetic methods, but it is generally isolated from plants or aromatic oils in industry. We could take clove basil which originating from Seychelles, Comoros as raw material. In 1965, it was introduced into China from the former Soviet Union. It is cultivated in the south of the Yangtze River. The clove basil content is the highest in spike, followed by leaves, and stems are the last. The main ingredient in the oil is eugenol, accounting for 60-70%. There are linalool, parachute, ocimene and so on. We could prepare eugenol by synthetic method, in which o-methoxyphenol reacts with bromopropene. And then rearrangement is carried out with heating.


Eugenol has a strong bactericidal and local anti-corrosive effect. It could be used for dental caries as a local analgesic drug. Eugenol is an intermediate of some other spices. Derivatives are eugenol, methyl eugenol, methyl isobutyl eugenol, acetylbutanoic eugenol, acetyl tauer eugenol, and benzyl isobornylphenol. When the eugenol is heated in potassium hydroxide, the double bond of propenyl is rearranged to form α-propenyl conjugated to the benzene ring to obtain isobutanol. Then acetylation and mild oxidation of isobutanol and α-propenyl cleavage is carried out. Finally we get vanillin, which is the main ingredient of an important artificial flavoring. Eugenol can also be used to prepare isonicid that is the specific drug for treatment of tuberculosis. It also could lower blood pressure.

Acute toxicity

Oral-LD50: 1930 mg/kg; Oral-Mouse LD50: 3000 mg/kg


analgesic (topical), antiseptic, antifungal

97-53-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (01050595)  Eugenol  primary pharmaceutical reference standard 97-53-0 01050595-100MG 2,634.84CNY Detail
USP (1268965)  Eugenol  United States Pharmacopeia (USP) Reference Standard 97-53-0 1268965-500MG 4,326.66CNY Detail
Sigma-Aldrich (E5000000)  Eugenol  European Pharmacopoeia (EP) Reference Standard 97-53-0 E5000000 1,880.19CNY Detail
Sigma-Aldrich (PHR1269)  Eugenol  pharmaceutical secondary standard; traceability to USP and PhEur 97-53-0 PHR1269-1G 732.19CNY Detail
Sigma-Aldrich (79891)  Eugenol  certified reference material, TraceCERT® 97-53-0 79891-100MG 1,075.23CNY Detail
Sigma-Aldrich (35995)  Eugenol  PESTANAL®, analytical standard 97-53-0 35995-250MG 329.94CNY Detail
TCI America (A0232)  Eugenol  >99.0%(GC) 97-53-0 500mL 990.00CNY Detail
TCI America (A0232)  Eugenol  >99.0%(GC) 97-53-0 100mL 430.00CNY Detail
TCI America (A0232)  Eugenol  >99.0%(GC) 97-53-0 25mL 180.00CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Engenol

1.2 Other means of identification

Product number -
Other names 4-allyl-2-methoxyphenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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