1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

Base Information

Chemical Name:1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride
CAS No.:137650-35-2
Molecular Formula:C₂₆H₃₇N₃O₂*2ClH
Molecular Weight:496.521
Hs Code.:

Synonyms:1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

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Chemical Property of 1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

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Technology Process of 1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

There total 8 articles about 1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(S)-2-(2-{[tert-Butoxycarbonyl-(3-phenyl-propyl)-amino]-methyl}-piperidin-1-yl)-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 137650-35-2
1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00080a005

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 137650-35-2
1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 37 percent / H₂, acetic acid / 5percent Pd/C / ethanol / 3102.9 Torr

2: 79 percent / Et₃N / CH₂Cl₂ / 3 h / 23 °C

3: H₂, conc. HCl / 5percent Pt/C / ethanol / 3102.9 Torr

4: 4-methylmorpholine / tetrahydrofuran / 1.5 h

5: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; platinum on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00080a005

Reference yield:

: 2038-57-5
3-Phenylpropan-1-amine

: 137650-35-2
1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<<(3-phenylpropyl)amino>methyl>piperidine dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 37 percent / H₂, acetic acid / 5percent Pd/C / ethanol / 3102.9 Torr

2: 79 percent / Et₃N / CH₂Cl₂ / 3 h / 23 °C

3: H₂, conc. HCl / 5percent Pt/C / ethanol / 3102.9 Torr

4: 4-methylmorpholine / tetrahydrofuran / 1.5 h

5: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; platinum on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00080a005