methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

Base Information

Chemical Name:methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate
CAS No.:1354709-95-7
Molecular Formula:C₂₅H₂₉N₃O₆
Molecular Weight:467.522
Hs Code.:

Synonyms:methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

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Chemical Property of methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

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Technology Process of methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

There total 3 articles about methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-10-8,42939-71-9
propylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1354709-93-5
methyl 2-amino-5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-benzoate

: 1354709-95-7
methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

Guidance literature:: bis(trichloromethyl) carbonate; methyl 2-amino-5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-benzoate; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

propylamine; With triethylamine; In 1,4-dioxane; for 18h; Inert atmosphere;

Reference yield:

: 1354709-92-4
methyl 2-amino-5-{[1-(benzyloxy)-2-methylindolizin-3-yl]carbonyl}benzoate

: 1354709-95-7
methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3.1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / Inert atmosphere

With ammonium formate; caesium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 944445-64-1
methyl 2-amino-5-[(1-hydroxy-2-methylindolizin-3-yl)-carbonyl]benzoate

: 1354709-95-7
methyl 5-{[1-(2-methoxyethoxy)-2-methylindolizin-3-yl]carbonyl}-2-[(propylcarbamoyl)amino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2.1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.2: 18 h / Inert atmosphere

With caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;