3,4-bis(benzyloxy)-6-ethenylpyridazine

Base Information

• Chemical Name: 3,4-bis(benzyloxy)-6-ethenylpyridazine
• CAS No.: 1425512-39-5
• Molecular Formula: C₂₀H₁₈N₂O₂
• Molecular Weight: 318.375
• Mol file: 1425512-39-5.mol

Synonyms:3,4-bis(benzyloxy)-6-ethenylpyridazine

Chemical Property of 3,4-bis(benzyloxy)-6-ethenylpyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-bis(benzyloxy)-6-ethenylpyridazine

There total 2 articles about 3,4-bis(benzyloxy)-6-ethenylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

trivinylboroxin (92988-08-4) + 3,4-bis(benzyloxy)-6-chloropyridazine (55826-72-7) → 3,4-bis(benzyloxy)-6-ethenylpyridazine (1425512-39-5)

Guidance literature:

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 3,4-bis(benzyloxy)-6-ethenylpyridazine (1425512-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 17.17 h / 0 - 25 °C

2: pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; mineral oil;

Reference yield: 71.0%

1-bromo-3,5-difluoro-4-trifluoromethylbenzene (156243-64-0) + 3,4-bis(benzyloxy)-6-ethenylpyridazine (1425512-39-5) → 3,4-bis(benzyloxy)-6-[(E)-2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethenyl]pyridazine (1425512-38-4)

Guidance literature:

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 120 ℃; for 2h; Microwave irradiation;

upstream raw materials:

trivinylboroxin

3,4-bis(benzyloxy)-6-chloropyridazine

benzyl alcohol

Downstream raw materials:

3,4-bis(benzyloxy)-6-[(E)-2-[3,4-bis(trifluoromethyl)phenyl]-ethenyl]pyridazine

6-{2-[3,4-bis(trifluoromethyl)phenyl]ethyl}-4-hydroxy-2,3-dihydropyridazine-3-one

3,4-bis(benzyloxy)-6-[(E)-2-[2-methyl-4-(trifluoromethyl)phenyl]ethenyl]pyridazine

3,4-bis(benzyloxy)-6-[(E)-2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethenyl]pyridazine

Refernces

• 1、 -. "NOVEL COMPOUNDS". . . Retrieved 2013/03/26.