Technology Process of 3,4-bis(benzyloxy)-6-[(E)-2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethenyl]pyridazine
There total 3 articles about 3,4-bis(benzyloxy)-6-[(E)-2-[3,5-difluoro-4-(trifluoromethyl)phenyl]ethenyl]pyridazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; triethylamine; tris-(o-tolyl)phosphine;
In
acetonitrile;
at 120 ℃;
for 2h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / mineral oil; tetrahydrofuran / 17.17 h / 0 - 25 °C
2: pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere
3: tris-(o-tolyl)phosphine; triethylamine; palladium diacetate / acetonitrile / 2 h / 120 °C / Microwave irradiation
With
pyridine; tetrakis(triphenylphosphine) palladium(0); palladium diacetate; sodium hydride; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; 1,4-dioxane; water; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere
2: tris-(o-tolyl)phosphine; triethylamine; palladium diacetate / acetonitrile / 2 h / 120 °C / Microwave irradiation
With
pyridine; tetrakis(triphenylphosphine) palladium(0); palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine;
In
1,4-dioxane; water; acetonitrile;