C₂₈H₃₃NO₄

Base Information

• Chemical Name: C₂₈H₃₃NO₄
• CAS No.: 1372874-81-1
• Molecular Formula: C₂₈H₃₃NO₄
• Molecular Weight: 447.574
• Mol file: 1372874-81-1.mol

Synonyms:C₂₈H₃₃NO₄

Chemical Property of C₂₈H₃₃NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₃NO₄

There total 5 articles about C₂₈H₃₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ibuprofen (15687-27-1,58560-75-1) + C15H17NO3 (1372874-80-0) → C28H33NO4 (1372874-81-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h; Darkness; Inert atmosphere;

DOI:10.1039/c2jm30357d

Reference yield:

N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide (3743-29-1) → C28H33NO4 (1372874-81-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: bismuth(III) chloride / 144 h / 75 °C

2.1: tetrabutylammomium bromide; potassium carbonate; sodium iodide / acetonitrile / 6 h / Reflux

3.1: selenium(IV) oxide / para-xylene / 24 h / Reflux; Inert atmosphere

3.2: 3 h / 20 °C

4.1: sulfuric acid / 1 h / 0 °C

5.1: tetrabutylammomium bromide; potassium carbonate; sodium iodide / acetone / 6 h / Reflux

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Darkness; Inert atmosphere

With dmap; selenium(IV) oxide; bismuth(III) chloride; sulfuric acid; tetrabutylammomium bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In dichloromethane; para-xylene; acetone; acetonitrile;

DOI:10.1039/c2jm30357d

Reference yield:

7-[N-(p-toluenesulfonyl)amino]-4-methylcoumarin (101973-09-5) → C28H33NO4 (1372874-81-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrabutylammomium bromide; potassium carbonate; sodium iodide / acetonitrile / 6 h / Reflux

2.1: selenium(IV) oxide / para-xylene / 24 h / Reflux; Inert atmosphere

2.2: 3 h / 20 °C

3.1: sulfuric acid / 1 h / 0 °C

4.1: tetrabutylammomium bromide; potassium carbonate; sodium iodide / acetone / 6 h / Reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C / Darkness; Inert atmosphere

With dmap; selenium(IV) oxide; sulfuric acid; tetrabutylammomium bromide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In dichloromethane; para-xylene; acetone; acetonitrile;

DOI:10.1039/c2jm30357d

upstream raw materials:

7-(ethylamino)-4-(hydroxylmethyl)coumarin

ibuprofen

C₁₅H₁₇NO₃

N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide

Downstream raw materials:

C₃₄H₄₉NO₇Si

Refernces