N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

Base Information

Chemical Name:N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine
CAS No.:718610-15-2
Molecular Formula:C₂₃H₃₀ClNO₄S₂
Molecular Weight:484.081
Hs Code.:

Synonyms:N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

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Chemical Property of N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

Chemical Property:

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Technology Process of N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

There total 7 articles about N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718610-66-3
N-(3-hydroxy-3-phenylpropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

: 718610-15-2
N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1122-97-0
4-methylsulfanyl-thiophenol

: 718610-15-2
N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

5.1: sodium tetrahydroborate / ethanol / 18 h / 20 °C

6.1: methanesulfonyl chloride; triethylamine / dichloromethane / 18 h / 20 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;

Reference yield:

: 718610-26-5
4-(2-[4-methanesulphonylphenylsulphonyl]ethyl)piperidine

: 718610-15-2
N-(3-phenyl-3-chloropropyl)-4-[2-(4-methanesulphonylphenylsulphonyl)ethyl]-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

2: sodium tetrahydroborate / ethanol / 18 h / 20 °C

3: methanesulfonyl chloride; triethylamine / dichloromethane / 18 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; methanesulfonyl chloride; triethylamine; In DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;