1122-97-0

Usage

Uses

Used in Pharmaceutical Industry:
4-(METHYLTHIO)THIOPHENOL is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Organic Chemical Synthesis:
4-(METHYLTHIO)THIOPHENOL serves as a building block in the creation of other organic chemicals, playing a crucial role in the chemical industry for the production of a wide range of products.
Used in Fragrance Industry:
4-(METHYLTHIO)THIOPHENOL is used as a fragrance ingredient in the formulation of soaps, cosmetics, and perfumes, adding unique scents and enhancing the sensory experience of these products.
Safety Considerations:
Due to its flammable nature and potential to release toxic fumes when heated, 4-(METHYLTHIO)THIOPHENOL requires careful handling and the implementation of proper safety measures during its use and storage.

InChI:InChI=1/C7H8S2/c1-9-7-4-2-6(8)3-5-7/h2-5,8H,1H3

Upstream product

• 106-46-7 para-dichlorobenzene 
• 5188-07-8 sodium thiomethoxide 
• 70398-91-3 4-(Methylthio)-phenyl isopropyl sulphide 
• 86636-07-9 p-(methylthio)phenyl benzyl sulphide 
• 104-95-0 (4-bromophenyl)thioanisole 
• 1129-25-5 4-(methylsulfanyl)benzenesulfonyl chloride 
• 76227-90-2 p-(Isopropylthio)-thiophenol 
• 7205-62-1 1-chloro-4-(isopropylthio)benzene 
• 699-20-7 1,4-Bis(methylthio)benzene 
• 127-09-3 sodium acetate 

Downstream Products

• 699-20-7 1,4-Bis(methylthio)benzene 
• 5202-08-4 2-<4-Methylmercapto-phenylmercapto-methyl>-benzoesaeure-aethylester 
• 32300-56-4 2-(p-Methylthiophenylthio)-1-propanol 
• 65999-55-5 2-[2-(4-Methylsulfanyl-phenylsulfanyl)-phenyl]-acetamide 
• 69360-57-2 1,3-Dichlor-2-<4-(methylthio)-phenylthio>-5-nitrobenzol 
• 54413-85-3 4-methoxy-6-{[4'-(methylthio)-phenyl]-thio}benzoic acid 
• 21552-35-2 [2,5-Dichloro-4-(4-methylsulfanyl-phenylsulfanylthiocarbonylamino)-phenyl]-dithiocarbamic acid 4-methylsulfanyl-phenyl ester 
• 38307-33-4 Allyl-p-(methylthio)phenylsulfid 
• 32300-24-6 1-p-Methylthiophenylthio-2-propanol 
• 70398-91-3 4-(Methylthio)-phenyl isopropyl sulphide 
• 89000-13-5 5-(4-Methylsulfanyl-phenylsulfanylmethyl)-1H-pyrimidine-2,4-dione 
• 63031-87-8 5-(4-Methylsulfanyl-phenylsulfanyl)-thiophene-2-sulfonic acid amide 
• 33932-80-8 4-(methylthio)phenyl phenyl sulfide 
• 16175-07-8 2-<2-(4-methylthiophenylthio)phenyl>acetic acid 

Relevant academic research and scientific papers

A simple, fast and chemoselective method for the preparation of arylthiols

An efficient and convenient method for the synthesis of arylthiols by reaction of sulfonyl chlorides with triphenylphosphine in toluene is reported.

Method of producing bis(4-alkylthiophenyl) disulfides

The present invention relates to a method of producing bis(4-alkylthiophenyl) disulfides characterized by (a) reducing directly a 4-alkylthiobenzenesulfonyl chloride, or (b) oxidizing a 4-alkylthiobenzenethiol obtained by reducing a 4-alkylthiobenzenesulfonyl chloride. The present invention is capable of producing the compound below useful as an intermediate of pharmaceuticals. STR1

Non-aqueous reduction of aromatic sulfonyl chlorides to thiols using a dichlorodimethylsilane-zinc-dimethylacetamide system

A new and efficient method for the non-aqueous reduction of sulfonyl chlorides to affored the corresponding thiols by use of a dichlorodimethylsilane-zinc-dimethylacetamide system was successfully developed. Various aromatic thiols were prepared in high yield by easy operation. Continuous reactions with the above reduction using the prepared thiol were also demonstrated.

SELECTIVE DEALKYLATIONS OF ARYL ALKYL ETHERS AND THIOETHERS BY SODIUM IN HMPA

The reaction of sodium with bis- and tris(alkoxy)benzenes in HMPA gives selectively the products of monodealkylation.The reaction proceeds through a dianion which fragments into an alkyl and an aryloxy anion.The positional selectivity of this fragmentation is governed by the structure of both the alkyl and aryloxy groups.With bis- and tris(alkoxy)benzenes which for symmetry reasons can afford aryloxy anions having the same basicity, the dealkylation involves exlusively the less substituted alkyl group.On the contrary, in the asymmetric terms, the positional selectivity of the dealkylation process is governed by the basicity of the aryloxy anion.On the basis of these concepts several efficient and synthetically useful reactions have been developed.In most cases the selectivity obtained in the present reactions in different from that observed with other previously developed methods which use sodium methoxide or sodium alkenethiolates in HMPA.It is shown that the appropriate choice of the reagent allows selective dealkylation of the desired alkoxy group of a poly(alkoxy)benzene.The reaction of sodium with bis(alkylthio)benzenes in HMPA gives the bis(mercapto)benzenes.If the reduction is carried out with a solution of sodium in HMPA, the reaction gives instead the products of monodealkylation.This however is not selective.It is suggested that in the case of thioethers the dealkylation products originate from the fragmentation of the radical anions.

Reactions of Polychlorobenzenes with Alkanethiol Anions in HMPA. A Simple, High-Yield Synthesis of Poly(alkylthio)benzenes

Reactions of the isomeric trichlorobenzenes and tetrachlorobenzenes and of pentachloro- and hexachlorobenzene with an excess of the sodium salt of the isopropanethiol, in HMPA, afforded the products of complete displacement of all the chlorine atoms present in the molecule.Similar substitutions were also obtained with EtSNa.The reactions with MeSNa were in some cases complicated by the competitive nucleophilic attack at the methyl group of the initially formed aryl methyl thioethers which are thus demethylated to afford thiophenols.

Substituted 2-phenyl-1,2,4-triazine-3,5(2H,4H)-diones, and coccidiostatic agents containing same

Novel substituted 2-phenyl-1,2,4-triazine-3,5-(2H,4H)-diones are described as well as a process for their manufacture. The novel compounds may be used as chemotherapeutics, especially as coccidiostatic agents.

Indenylacetic acid compounds

4, 5, 6 or 7 Aryl substituted indenyl acetic acids and pharmaceutically acceptable salts, amides and esters thereof. The 4, 5, 6 or 7 aryl substituted indenyl acetic acids have anti-inflammatory, anti-pyretic and analgesic activity. The invention also includes methods for the preparation of these compounds, pharmaceutical compositions and methods of treating inflammation by administering these particular compounds to patients.