[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

Base Information

Chemical Name:[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid
CAS No.:917200-88-5
Molecular Formula:C₃₄H₃₉FO₃
Molecular Weight:514.68
Hs Code.:

Synonyms:[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

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Chemical Property of [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

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Technology Process of [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

There total 10 articles about [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917025-54-8
[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester

: 917200-88-5
[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

Guidance literature:: [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid methyl ester; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 25h;

With ammonium chloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 865236-07-3
4-(1-ethyl-1-(4-[(E)-2-(1-hydroxycyclopentyl)-vinyl]-3-methylphenyl)propyl)-2-methylphenol

: 917200-88-5
[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0.17 h / -10 °C

2: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 7 h / 80 °C

3: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 2 h / 100 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 25 h / 20 °C

With pyridine; sodium hydroxide; potassium phosphate; water; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 865236-04-0
4-(1-ethyl-1-[4-(1-hydroxycyclopentylethynyl)-3-methylphenyl]propyl)-2-methylphenol

: 917200-88-5
[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 4 h / 0 °C

2: pyridine / dichloromethane / 0.17 h / -10 °C

3: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 7 h / 80 °C

4: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 2 h / 100 °C

5: sodium hydroxide; water / tetrahydrofuran; methanol / 25 h / 20 °C

With pyridine; sodium hydroxide; potassium phosphate; water; potassium acetate; sodium bis(2-methoxyethoxy)aluminium dihydride; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;