sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

Base Information

Chemical Name:sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate
CAS No.:917023-46-2
Molecular Formula:C₃₄H₃₈FO₃*Na
Molecular Weight:536.662
Hs Code.:

Synonyms:sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

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Chemical Property of sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

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Technology Process of sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

There total 11 articles about sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917200-88-5
[4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methyl-biphenyl-4-yl]-acetic acid

: 917023-46-2
sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

Guidance literature:: With sodium methylate; In methanol;

Reference yield:

: 865236-07-3
4-(1-ethyl-1-(4-[(E)-2-(1-hydroxycyclopentyl)-vinyl]-3-methylphenyl)propyl)-2-methylphenol

: 917023-46-2
sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0.17 h / -10 °C

2: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 7 h / 80 °C

3: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 2 h / 100 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 25 h / 20 °C

5: sodium methylate / methanol

With pyridine; sodium hydroxide; potassium phosphate; water; sodium methylate; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 865236-04-0
4-(1-ethyl-1-[4-(1-hydroxycyclopentylethynyl)-3-methylphenyl]propyl)-2-methylphenol

: 917023-46-2
sodium [4'-(1-ethyl-1-{4-[(E)-2-(1-hydroxy-cyclopentyl)-vinyl]-3-methyl-phenyl}-propyl)-3-fluoro-2'-methylbiphenyl-4-yl]-acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 4 h / 0 °C

2: pyridine / dichloromethane / 0.17 h / -10 °C

3: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 7 h / 80 °C

4: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 2 h / 100 °C

5: sodium hydroxide; water / tetrahydrofuran; methanol / 25 h / 20 °C

6: sodium methylate / methanol

With pyridine; sodium hydroxide; potassium phosphate; water; sodium methylate; potassium acetate; sodium bis(2-methoxyethoxy)aluminium dihydride; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;