7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate

Base Information

• Chemical Name: 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate
• CAS No.: 1372854-72-2
• Molecular Formula: C₂₄H₃₄N₅O₁₇P₃
• Molecular Weight: 757.479

Synonyms:7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate

Chemical Property of 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate

There total 11 articles about 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyguanosine → 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate (1372854-73-3) + 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate (1372854-72-2)

Guidance literature:

7-[1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyguanosine; With trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; at 0 ℃; for 6h; Inert atmosphere;

With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; for 1h; pH=7.5; Inert atmosphere;

Reference yield:

(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol (1372854-34-6) → 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate (1372854-73-3) + 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate (1372854-72-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 0.75 h / 115 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: N,N,N',N'-tetramethylguanidine; 2-pyridinealdoxime / N,N-dimethyl-formamide; 1,4-dioxane / 70 °C / Inert atmosphere

4.1: trichlorophosphate; trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 6 h / 0 °C / Inert atmosphere

4.2: 0.17 h / 20 °C / Inert atmosphere

4.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

With trimethyl phosphite; 2-pyridinealdoxime; tetrabutyl ammonium fluoride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

3-iodo-4-nitroanisol (214279-40-0) → 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate (1372854-73-3) + 7-[(R)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine-5'-triphosphate (1372854-72-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: phenylmagnesium chloride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

1.2: 3 h / -40 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: 0.75 h / 115 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4.1: N,N,N',N'-tetramethylguanidine; 2-pyridinealdoxime / N,N-dimethyl-formamide; 1,4-dioxane / 70 °C / Inert atmosphere

5.1: trichlorophosphate; trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 6 h / 0 °C / Inert atmosphere

5.2: 0.17 h / 20 °C / Inert atmosphere

5.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

With trimethyl phosphite; 2-pyridinealdoxime; phenylmagnesium chloride; tetrabutyl ammonium fluoride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

pivalaldehyde

(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

3-iodo-4-nitroanisol

C₁₁H₁₂ClIN₄O₃

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