N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

Base Information

Chemical Name:N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride
CAS No.:1071484-09-7
Molecular Formula:C₃₁H₃₃FN₆OS₂*ClH
Molecular Weight:625.234
Hs Code.:

N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

Synonyms:N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

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Chemical Property of N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

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Technology Process of N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

There total 5 articles about N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1071483-68-5
3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide

: 1489-69-6
Cyclopropanecarboxaldehyde

: 149-73-5
trimethyl orthoformate

: 1071484-09-7
N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

Guidance literature:: 3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide; Cyclopropanecarboxaldehyde; trimethyl orthoformate; With acetic acid; In N,N-dimethyl-formamide; at 23 ℃; for 1.5h;

With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 23 ℃;

With hydrogenchloride; water; acetic acid; more than 3 stages;

Reference yield:

: 40481-13-8
4-phenyl-4-cyanopiperidine

: 1071484-09-7
N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 2 h / 23 °C

2.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 264 h / 2585.81 Torr

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 23 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

4.2: pH ~ 7

5.1: acetic acid / N,N-dimethyl-formamide / 1.5 h / 23 °C

5.2: 23 °C

With hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 158144-79-7
tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate

: 1071484-09-7
N-((1-(cyclopropylmethyl)-4-phenylpiperidin-4-yl)methyl)-3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 264 h / 2585.81 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 23 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 23 °C

3.2: pH ~ 7

4.1: acetic acid / N,N-dimethyl-formamide / 1.5 h / 23 °C

4.2: 23 °C

With hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;