(4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

Base Information

Chemical Name:(4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol
CAS No.:496051-91-3
Molecular Formula:C₂₃H₃₀NO₄P
Molecular Weight:415.469
Hs Code.:

Synonyms:(4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

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Chemical Property of (4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

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Technology Process of (4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

There total 3 articles about (4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

: 1608-26-0
Hexamethylphosphorous triamide

: (2S,3R,4R,5S)-3,4-O-isopropylidene-1,6-diphenyl-2,3,4,5-hexanetetraol

: 496051-91-3
(4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

Guidance literature:: With ammonium chloride; In toluene; for 8h; Heating;
DOI:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2

Reference yield:

: phenylmagnesium bromide

: 496051-91-3
(4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuBr*SMe₂ / diethyl ether / 2 h / -40 °C

1.2: 76.1 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 92.4 percent / NH₄Cl / toluene / 8 h / Heating

With copper(I) bromide dimethylsulfide complex; ammonium chloride; In diethyl ether; toluene;
DOI:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2

Reference yield:

: 63699-97-8
1,2:5,6-dianhydro-3,4-O-methylethylidene-L-iditol

: 496051-91-3
(4S,5S,6S,7S)-5,6-O-isopropylidene-2-(dimethylamino)-4,7-dibenzyl-1,3,2-dioxaphosphepane-5,6-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuBr*SMe₂ / diethyl ether / 2 h / -40 °C

1.2: 76.1 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 92.4 percent / NH₄Cl / toluene / 8 h / Heating

With copper(I) bromide dimethylsulfide complex; ammonium chloride; In diethyl ether; toluene;
DOI:10.1002/1099-0682(200210)2002:10<2614::AID-EJIC2614>3.0.CO;2-2