1608-26-0

Basic information

• Product Name: Hexamethylphosphorous triamide
• Synonyms: Hexamethylphosphorous triamide ,98％;Tris(dimethylamino)phosphine,HMPT, Hexamethylphosphorous triamide;Hexamethylphosphorous triamide 5g [1608-26-0];HexaMethylphosphorous triaMide, 97% 10ML;N,N,N',N',N'',N''-HexaMethyl-phosphorous TriaMide;NSC 102707;HEXAMETHYLTRIAMINOPHOSPHINE FOR SYNTHESI;N,N,N',N',N'',N''-hexaMethylphosphinetriaMine
• CAS NO: 1608-26-0
• Molecular Formula: C₆H₁₈N₃P
• Molecular Weight: 163.2
• EINECS: 216-534-4
• Product Categories: organophosphorus ligand;Miscellaneous Reagents;Phosphorylating and Phosphitylating Agents
• Mol File: 1608-26-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: -44 °C
• Boiling Point: 48-50 °C12 mm Hg(lit.)
• Flash Point: 73 °F
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 0.898 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.4mmHg at 25°C
• Refractive Index: n20/D 1.463(lit.)
• Storage Temp.: Store at RT.
• PKA: 8.03±0.70(Predicted)
• Water Solubility: REACTS
• Sensitive: Moisture Sensitive
• Stability: Stable. Highly flammable - note low flash point. Incompatible with oxidizing agents.
• BRN: 906778
• CAS DataBase Reference: Hexamethylphosphorous triamide(CAS DataBase Reference)
• NIST Chemistry Reference: Hexamethylphosphorous triamide(1608-26-0)
• EPA Substance Registry System: Hexamethylphosphorous triamide(1608-26-0)

Safety Data

• Hazard Codes: T,Xi,Xn,F
• Statements: 45-46-10-40-36/37/38
• Safety Statements: 53-45-36/37/39-26-16-37/39-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• RTECS: TH3390000
• F: 10
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 1608-26-0(Hazardous Substances Data)

Usage

Chemical Properties

colourless liquid

Uses

Different sources of media describe the Uses of 1608-26-0 differently. You can refer to the following data:
1. Hexamethylphosphorous triamide can be widely used in industry, with applications such as being a flame retardant for building materials to a phosphorylating agent in synthetic chemistry. It is a classified carcinogen.
2. Hexamethylphosphorous triamide can be uesd in suzuki reaction.
3. Hexamethylphosphorous triamide can be combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations.

Purification Methods

It may contain more than 1% of phosphoric triamide. The yellow oil is first distilled at atmospheric pressure, then under reduced pressure and stored under N2. It is air sensitive, TOXIC, and should not be inhaled. It is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973, Beilstein 4 IV 274.]

InChI:InChI=1/C6H18N3P/c1-7(2)10(8(3)4)9(5)6/h1-6H3

Upstream product

• 683-85-2 N,N-dimethylaminodichlorophosphane 
• 3348-44-5 bis(N,N-dimethylamino)chlorophosphine 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 49778-01-0 iminotris(dimethylamino)phosphorane 
• 1232774-92-3 1,1-bis(dimethylamino)-N,N-dimethyl-N'-[4-(trifluoromethyl)phenyl]phosphinecarboximidamide 
• 5574-93-6 chlorotris(dimethylamino)phosphonium chloride 
• 53617-91-7 C₁₁H₁₉N₂OP 
• 863650-34-4 C₁₈H₃₀N₄O₂P₂ 
• 244775-40-4 naphthalene-1,5-diylbis(dimethylphosphoramidite) 
• 863650-26-4 C₁₈H₃₀N₄O₂P₂ 
• 863650-20-8 C₁₈H₃₀N₄O₂P₂ 
• 26546-75-8 phenyl tetramethylphosphorodiamidite 
• 13754-82-0 N,N,N',N',N'',N''-hexamethylphosphorohydrazonic triamide 
• 20727-59-7 tetrakis(dimethylamino)phosphonium iodide 

Downstream Products

• 36636-04-1 benzyltris(dimethylamino)phosphonium chloride 
• 70794-36-4 (2-chloro-benzyl)-tris-dimethylamino-phosphonium; chloride 
• 57389-77-2 tris-dimethylamino-[(2,4-dioxo-3-phenyl-thiazolidin-5-yl)-phenyl-methyl]-phosphonium betaine 
• 13815-46-8 N,N-dimethylcyclohex-1-enylamine 
• 14205-42-6 3-dimethylamino-crotonic acid ethyl ester 
• 62419-12-9 Dimethylamino-dianilino-phosphan 
• 29166-07-2 Benzamidin 
• 32317-47-8 (1-ethyl-propenyl)-dimethyl-amine 
• 39939-18-9 C₁₁H₁₇N₂O₂P 
• 20685-43-2 Z-5-methyl-4-hepten-3-one 
• 20685-44-3 E-5-methyl-4-hepten-3-one 
• 23574-92-7 2-[3-(tris-dimethylamino-λ⁵-phosphanylidene)-triaz-1-enyl]-benzothiazole 
• 116149-64-5 C₂₃H₃₁N₄O₃P 
• 5577-13-9 Tosylurethane 

Relevant articles and documents

Phosphorylation of chitin with tris(dimethylamino)phosphine

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Novel Di-isopropylamino Derivatives of Trivalent Phosphorus

Reduction of (iPr2N)2PCl with LiAlH4 in diethyl ether gives (iPr2N)2PH; reaction of iPr2NPCl2 with Mg in boiling tetrahydrofuran gives either the cyclotetraphosphine (iPr2N)4P4 or the 1,2-dichlorobiphosphine iPr2NP(Cl)-P(Cl)NiPr2 depending upon the Mg:iPr2NPCl2 mole ratio.

Cyclization of C-phosphorylated (PIII) arylformamidines to 3H-1,3-benzazaphospholes

A synthesis of 3H-1,3-benzazaphospholes starting from C-phosphorylated P(III) arylformamidines has been developed. Electron-donating substituents were found to enhance markedly the rate of the cyclization, with substituents at the meta position having the greatest effect. A plausible mechanism of the cyclization was proposed based on DFT calculations.

Dismutation of diamidoarylphosphites

Some examples of spontaneous dismutation of diamidoarylphosphites in different solvents were studied, and features of the process were revealed.