ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate

Base Information

• Chemical Name: ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate
• CAS No.: 784149-92-4
• Molecular Formula: C₂₄H₂₈N₂O₅
• Molecular Weight: 424.497
• Mol file: 784149-92-4.mol

Synonyms:ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate

Chemical Property of ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate

There total 7 articles about ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine (784149-40-2) + ethyl 2-ethoxyethanoate (817-95-8) → ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate (784149-92-4)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -50 ℃; for 3h;

DOI:10.1016/j.bmcl.2006.08.110

Reference yield:

5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine (157169-61-4) → ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate (784149-92-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / NaBH₄ / methanol / 1 h / 20 °C

2: 100 percent / (COCl)2 / dimethylformamide; CH₂Cl₂ / 3 h / 20 °C

3: 75 percent / NaI / acetone / 4 h / 20 °C

4: NaHMDS / tetrahydrofuran / 3 h / -50 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium hexamethyldisilazane; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; 3: Finkelstein reaction;

DOI:10.1016/j.bmcl.2006.08.110

Reference yield:

5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine (784149-29-7) → ethyl 2-ethoxy-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoate (784149-92-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: nBuLi / diethyl ether; tetrahydrofuran / -78 °C

1.2: 72 percent / diethyl ether; tetrahydrofuran / 1 h / 0 °C

2.1: 100 percent / NaBH₄ / methanol / 1 h / 20 °C

3.1: 100 percent / (COCl)2 / dimethylformamide; CH₂Cl₂ / 3 h / 20 °C

4.1: 75 percent / NaI / acetone / 4 h / 20 °C

5.1: NaHMDS / tetrahydrofuran / 3 h / -50 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; 4.1: Finkelstein reaction;

DOI:10.1016/j.bmcl.2006.08.110

upstream raw materials:

5-(iodomethyl)-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine

ethyl 2-ethoxyethanoate

5-formyl-2-[2-(5-methyl-2-phenyl-4-oxazolyl)-ethoxy]pyridine

5-bromo-2-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridine