(R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester

Base Information

• Chemical Name: (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester
• CAS No.: 81440-39-3
• Molecular Formula: C₂₅H₂₄N₂O₅S
• Molecular Weight: 464.542
• Mol file: 81440-39-3.mol

Synonyms:(R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester

Chemical Property of (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester

There total 3 articles about (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-benzyl N-(benzyloxycarbonyl)-D-aspartate o-mercaptoanilide, disulfide derivative (81440-38-2) → (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester (81440-39-3)

Guidance literature:

With acetic acid; zinc; at 50 ℃;

DOI:10.1021/jm00369a016

Reference yield:

benzyl (-)-(R)-4-chloro-4-oxo-2-<<(benzyloxy)carbonyl>amino>butyrate (75626-73-2) → (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester (81440-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / i-Pr₂NEt / 4 h / 4 °C

2: Zn, glacial AcOH / 50 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; zinc;

DOI:10.1021/jm00369a016

Reference yield:

2-Aminophenyl disulfide (1141-88-4) → (R)-2-Benzyloxycarbonylamino-N-(2-mercapto-phenyl)-succinamic acid benzyl ester (81440-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / i-Pr₂NEt / 4 h / 4 °C

2: Zn, glacial AcOH / 50 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; zinc;

DOI:10.1021/jm00369a016

upstream raw materials:

α-benzyl N-(benzyloxycarbonyl)-D-aspartate o-mercaptoanilide, disulfide derivative

benzyl (-)-(R)-4-chloro-4-oxo-2-<<(benzyloxy)carbonyl>amino>butyrate

2-Aminophenyl disulfide

Downstream raw materials:

(R)-3-Benzothiazol-2-yl-2-benzyloxycarbonylamino-propionic acid benzyl ester

(R)-2-Amino-3-benzothiazol-2-yl-propionic acid