5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

Base Information

• Chemical Name: 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione
• CAS No.: 78451-20-4
• Molecular Formula: C₂₈H₂₇N₃O₄S
• Molecular Weight: 501.606
• Mol file: 78451-20-4.mol

Synonyms:5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

Chemical Property of 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

There total 4 articles about 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,5-dimethoxybenzaldehdye (7311-34-4) + 1-Phenyl-3-(2'-pyridinobutan-4'-yl)thiobarbituric Acid (78451-18-0) → 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (78451-20-4)

Guidance literature:

With acetic acid; In ethanol; for 8h; Heating;

Reference yield:

2-(4-Aminobutyl)pyridine (34974-00-0) → 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (78451-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / benzene / 2 h / Heating

2: 62 percent / CH₃COCl / 1 h / Heating

3: 80 percent / glacial CH₃COOH / ethanol / 8 h / Heating

With acetic acid; acetyl chloride; In ethanol; benzene;

Reference yield:

phenyl isothiocyanate (103-72-0) → 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (78451-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / benzene / 2 h / Heating

2: 62 percent / CH₃COCl / 1 h / Heating

3: 80 percent / glacial CH₃COOH / ethanol / 8 h / Heating

With acetic acid; acetyl chloride; In ethanol; benzene;

upstream raw materials:

3,5-dimethoxybenzaldehdye

1-Phenyl-3-(2'-pyridinobutan-4'-yl)thiobarbituric Acid

2-(4-Aminobutyl)pyridine

phenyl isothiocyanate