34974-00-0

Usage

InChI:InChI=1/C9H14N2/c10-7-3-1-5-9-6-2-4-8-11-9/h2,4,6,8H,1,3,5,7,10H2

Upstream product

• 109-06-8 α-picoline 
• 6276-54-6 3-chloropropylamine hydrochloride 
• 15582-85-1 2-Pyridinebutanamide 
• 60257-19-4 4-(2-pirydyl)butyronitrile 
• 100-69-6 2-vinylpyridine 
• 84199-92-8 diethyl 2-(2-pyridyl)ethylmalonate 
• 84199-93-9 2-(3-ethoxycarbonylpropyl)pyridine 

Downstream Products

• 78451-18-0 1-Phenyl-3-(2'-pyridinobutan-4'-yl)thiobarbituric Acid 
• 78451-16-8 1-Phenyl-3-(2'-pyridinobutan-4'-yl)-5-benzylidene-thiobarbituric Acid 
• 78451-25-9 5-[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78451-22-6 5-[1-(3,4-Dihydroxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78468-69-6 5-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78451-21-5 5-[1-(4-Nitro-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78451-20-4 5-[1-(3,5-Dimethoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78451-23-7 5-[1-(3-Bromo-5-hydroxy-4-methoxy-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78468-70-9 5-[1-(4-Hydroxy-3-methoxy-5-nitro-phenyl)-meth-(Z)-ylidene]-1-phenyl-3-(4-pyridin-2-yl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 78451-17-9 1-Phenyl-3-(2'-pyridinobutan-4'-yl)thiourea 

Relevant academic research and scientific papers

Structural Factors Affecting the Basicity of ω-Pyridylalkanols, ω-Pyridylalkanamides and ω-Pyridylalkylamines

The present paper describes the preparation by conventional methods (when not available commercially) and the pKa-determination of the α-, β- and γ-isomers of pyridylethanamide, 3-pyridylpropanamide, 4-pyridylbutanamide, 5-pyridylpentanamide, pyridylmethanol, 2-pyridylethanol, 3-pyridylpropanol, 4-pyridylbutanol, 5-pyridylpentanol, pyridylmethylamine, 2-pyridylethylamine, 3-pyridylpropylamine, 4-pyridylbutylamine, and 5-pyridylpentylamine.While a field effect accounts for many variations in pKa as a function of chain length, marked inductive effects are operative in some methyl and ethyl homologs.The pKa-decreasing influence of an intramolecular H-bond is also apparent in some lower homologs belonging to the α-series.

5-(HYDROXYPYRIDYLALKYL)-4-PYRIMIDONES

The compounds are substituted 2-amino-4-pyrimidones with a 5-(hydroxypyridylalkyl) substituent which are histamine H 2-antagonists. Two specific compounds are 2-2-(3-bromo-2-pyridylmethylthio) ethylamino!-5-(2-hydroxy-4-pyridylmethyl)-4-pyrimidone and 2-4-(3-methoxy-2-pyridyl)butylamino!-5-(2-hydroxy-4-pyridylmethyl)-4-pyrimido ne.

PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING H-1 AND H-2 HISTAMINE RECEPTORS

Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-2-((4-methyl-5-imidazolyl)-methylthio)ethyl!guanidine. "