(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

Base Information

Chemical Name:(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide
CAS No.:110613-85-9
Molecular Formula:C₂₅H₄₈N₂O₅
Molecular Weight:456.667
Hs Code.:

Synonyms:(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

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Chemical Property of (2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

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Technology Process of (2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

There total 4 articles about (2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1068-55-9
isopropylmagnesium chloride

: 104371-34-8
(2R,4S,5S)-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxy-2-(N-isobutylcarbamoyl)hex-1-ene 1,2-oxide

: 110613-85-9
(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.75h;
DOI:10.1021/jm00394a008

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 110613-85-9
(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

3: 25 percent / tetrahydrofuran; diethyl ether / 0.75 h / 0 °C

With triisopropoxytitanium(IV) chloride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00394a008

Reference yield:

: 77077-15-7
N-isobutylmethacrylamide

: 110613-85-9
(2S,3S,5S)-N-isobutyl-2-<<(tert-butyloxy)carbonyl>amino>-1-cyclohexyl-3,5-dihydroxy-7-methyloctane-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

3: 25 percent / tetrahydrofuran; diethyl ether / 0.75 h / 0 °C

With triisopropoxytitanium(IV) chloride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm00394a008